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READY-TO-USE FILM COATING

PHARMA ACRYLIC POLYMERS

COOLING COMPOUNDS

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R & D COATER

FILM COATING - NUTRACEUTICALS

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Pharma Acrylic Polymers

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ECOPOLTM L 100

Description:

ECOPOL™ L 100 is a ready-to-mix  enteric coating system reconstituted using hydro-alcoholic system as solvent with addition of plasticizer, glidant & colourants.

imageRecommended Solvent System:

  • For total batch size of 1.0 Kg, 70.0 gm of ECOPOL™ L 100 is required with 1235.55 gm of Isopropyl alcohol + Purified water (9:1) as total solids content is 8.0 %.
  • IPA + Purified Water (8:2) can also be used.

           
Equipment:

  • Stainless steel vessel with a capacity that is 25% higher than the total dispersion volume.
  • The height of the vessel should be nearly 25% more than its diameter.
  • The speed of the propeller stirrer should be variable and its blade diameter should be nearly 1/3rd of the vessel diameter. (As shown in Figure, h > d and ds = (1/ 3)d)

Reconstitution procedure:

  • Take recommended quantity of ECOPOLTM L 100 into 500 gm of IPA + Purified Water (9:1) mixture at continuous stirring. Continue the stirring up to 45 mins till the clear solution is formed.
  • Take recommended quantity of Titanium Dioxide, colourants, talc & plasticizer (DBS or DEP or TEC) & Polysorbate 80/60 in to balance part of IPA + Purified Water (9:1) or (8:2) mixture. Pass the dispersion through Colloidal mill/homogenizer and homogenize for 10 mins & filter the homogenized/colloidal dispersion through # 80 mesh.
  • Add the colloidal dispersion in to ECOPOLTM L 100 solution & continue the stirring during the entire coating process.

Precautions:

  • The use of high speed stirrer or homogenizer is not recommended.
  • The prepared dispersion should not be passed through colloid mill.
  • The dispersion may need gentle stirring during the operation to prevent settling.

Coating parameters for ECOPOL™L 100:

Parameters
Auto coater
Auto coater
Conventional Pan
Conventional Pan
Pan diameter
24”
48”
60”
12”
36”
Solvent
Hydro-alcoholic
Hydro-alcoholic
Hydro-alcoholic
Hydro-alcoholic
Hydro-alcoholic
Solids content (% w/w)
8.0
8.0
8.0
8.0
8.0
Pan speed* (rpm)
10-14
3-5
1.5-3
18-20
8-12
Baffles
4-6
6-8
6-10
3
4
Tablet charge**(kg)
10-15
100-130
250-300
0.5-1
40-50
Tablet bed temperature (ºC)
30 – 35
30 -35
30 -35
30 – 35
30 - 35
Spray nozzle (mm)
1
1.2-1.5
1.2-1.5
1
1.2
Number of spray guns
1
2-3
4-6
1
1
Atomizing air pressure (bars)
1.5-2.5
2-2.8
2-3.0
1.2-1.8
1.5-2.2
Spray procedure
Continuous
Continuous
Continuous
Continuous
Continuous
Spray rate (g/min)
20-25
120-140
200-250
4-8
50-60
Inlet air temperature (ºC)
40-50
40-50
40-50
40-50
40-50
Weight gain (%)
8
8
8
8
8

* Pan speed would depend upon the tablet shape, size, friability and the number of baffles, so as to effect proper mixing during the coating process.
** Tablet charge would vary depending upon the tablet shape and size.